Study of the magnitude of bronchial resistance

A study of the magnitude of bronchial resistance by the method of pneumotachography in patients with HO BL occurring on the background of CLL showed a significant increase in R aw compared with similar indicators in the control group (healthy) and a slight increase compared with the data of patients with COPD without an associated lymphoproliferative disease. Once contrast performance values Bron hialnogo resistance at Paci ENTOV primary and third control groups can be explained by the fact that in some patients of Group III at baseline, these figures are slightly higher due to specific bronchial pulmonary manifestations limfoley goat and latent course of chronic Cesky obstructive bronchi that.

On average, in the morning, the PSV indices, with peak flowmetry, were 47% D and in the evening 52% D. Changes in the HRP within a day did not significantly exceed 5%. There were no significant differences in the PSV indices and its daily fluctuations in patients of the main and 3rd control group.

In order to study microhemocirculation in the proximal bronchial tree, 10 patients with COPD associated with CLL (2 patients from I, 6 from II, and 2 from III groups) underwent endobronchial LDF on a laser analyzer of capillary blood flow LAAC-02. Disorders of microcirculatory blood flow were diagnosed in all patients. PM has been significantly reduced. The σ values ​​were lower than the control values. Kv was significantly higher than control. Correlations were found between the intensity of inflammation in the bronchi and a decrease in PM (r = –0.57; P <0.05), between a decrease in FEV 1 and PM (r = 0.46; P <0.05). However, it should be borne in mind that in patients with CLL outside of the attachment of AML, there is an initial decrease in PM.

During the amplitude-frequency analysis of the Dopplerograms, it was found that the amplitudes of oscillations in the E-band, in patients with COPD were lower than the control values ​​(P <0.01). This can be explained by a decrease in endothelial oscillations in patients with COPD, without concomitant hemoble astrosis [238], since in patients with CLL, outside the administration of AML, there are no changes in endothelial oscillations .

The amplitude of oscillations in the H-band, associated with the sympathetic effects on smooth muscle cells of arterioles and arteriolar regions of arterio-veno-vulvar anastomoses was increased compared with the control. An increase in the amplitude of oscillations in this frequency range indicates arteriolar vasodilation, which can be explained by the presence of a broncho-obstructive process, since the majority of COPD patients have severe and moderate degrees who do not have hemoblastosis and increased neurogenic fluctuations. Dilation of arteriol can be an adaptive response of the microcirculatory bed, since it contributes to the optimal blood flow to the capillaries in patients with leukostasis.

The amplitudes of oscillations in the M and D bands, indicating the activity of local x pacemakers inside the smooth muscle cells of the precapillary sphincters and venous tone, did not differ from the control.

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