In patients with MM of group III, pr and carrying out zonal lung reography , there is a decrease in general and regional ventilation of the lungs. A significant decrease in ventilation in all zones of both lungs and a decrease in the total MOBP from all zones of the lungs by 48.8% (P <0.001) were diagnosed. There is a redistribution of ventilation from the lower and middle to the upper zones of both lungs . A decrease in the pulsatory blood flow in both lungs was diagnosed. The cumulative MPCr index is reduced compared with the control by 46.5% (P <0.001) . In group III, due to uremic damage of the heart and blood vessels, the precapillary vascular resistance reaches maximum values. In patients with renal failure, a significant increase was diagnosed. DSC in the middle and lower zones of both lungs. In group III, the VPO in the right lung had no significant differences compared with the control (p> 0.05). On the left, the overall indicator of HPE was reduced (p <0.05), due to a decrease in the VPO of the lower zone (p <0.001). The HPE of both lungs in group III patients did not have significant differences with the control group (1.1 ± 0.053; p> 0.05).
In patients of group I, the pO2 indicator did not significantly differ from that in the control group. The decrease in pO2 in patients of groups II and III is explained by the progression of regional ventilation disorders as the tumor process develops in patients with MM. The leading role in the disturbance of blood gas composition in MM is associated with a decrease in ventilation and lung perfusion, but the progression of the anemic syndrome as the tumor process develops also plays an important role .
In group I, the SrDLA index (14.67 ± 0.5 mm Hg) did not have significant differences compared with the control group (14.99 ± 0.61 mm Hg; P> 0.05). Patients II (18.7 ± 1.0 mm Hg; P <0.05) and III (22.8 ± 0.5 mm Hg; P <0.001) of the groups showed a significant increase in SrDLA compared to control.
Echocardiography and ICGD were performed on 50 patients with MM aged 33 to 70 years without concomitant COPD (12 patients from I, 27 of II, and 11 of Group III). Patients with diseases accompanied by a primary lesion of the left heart were excluded from the study. Pulmonary hypertension was diagnosed in 26 patients (52%). The SrDLA index in these patients was within 21–39 mm Hg, and averaged 23 ± 0.9 mm Hg. All patients with PH belonged to groups II and III (17 and 9 people, respectively). In patients with renal insufficiency, the highest rates of SrDLA were noted. In 24 patients (48%), the average SrDLA in rest did not exceed 20 mm. Hg Art. Of these, in 17 people it was within 9–16 mm. Hg Art. and in 7 – 17 – 20 mm. Hg Art.