Leukostasis risk

When conducting this study, CLL patients were divided into two subgroups. When leukocytosis is more than 50 × 10 9 / L , the risk of development of leukostasis in the vessels of the lungs increases significantly, and when leukocytosis is more than 200 × 10 9 / L, leukostasis almost always develops . The first subgroup included 10 patients with benign course of CLL (from group I), leukocytosis in peripheral blood of which did not exceed 50 × 10 9 / l. The second subgroup consisted of 15 patients from groups II and III, with the level of leukocytes in peripheral blood from 100 to 850 × 10 9 / l.

The indicator of the microcirculation parameter (PM), which characterizes the state of tissue perfusion, was significantly decreased as the CLL progressed and leukocytosis increased in peripheral blood (Table 10). In patients of the first subgroup, the PM index, despite its decline in some patients, was generally not significantly different from the PM index in healthy individuals. Patients of the second subgroup were diagnosed with a significant decrease in PM . A reliable inverse correlation was established between the level of leukocytosis and a decrease in PM (r = –0.75, P <0.01), between the duration of CLL disease and a decrease in PM (r = –0.6, P <0.05).

The values ​​of the mean square deviation of PM (σ), reflecting the preservation of the mechanisms of blood flow regulation in the microcirculatory bed, did not differ in patients of both subgroups from the control group . The coefficient of variation (Kv), which characterizes the dependence of tissue perfusion on the modulation of blood flow, increased during the tumor progression and in the second subgroup significantly exceeded the control .

When analyzing the rhythmic components of blood flow oscillations, no significant differences in the e-range of patients with CLL have all x subgroups (P> 0.05) . Fluctuations in the e-range on the dopplerograms are due to the metabolic activity of the vascular endothelium, namely the production of nitric oxide. Since no endothelial fluctuations were diagnosed in CLL patients, it was concluded that there were no significant impairments to the metabolic activity of the vascular endothelium of the microcirculatory bed, in this disease.

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