In patients of group I, there was a slight dilatation of capillaries, a plethora of arterioles, capillaries and venules. In patients with CLL in stage A, no leucostasis was found in the vessels of the microcirculatory bed of the bronchi. In patients with group II, dilatation and plethora of arterioles, capillaries, and venules were observed with varying degrees of severity. In 6 patients of group II, accumulations of lymphocytes with the formation of leuco- stasis were observed in the vessels of the microcirculatory bed. In patients with group III, dilatation of arterioles, capillaries and venules was also diagnosed with varying degrees of severity. All group III patients were diagnosed with leukostasis in the vessels of the microcirculatory bed.
In order to study microhemocirculation in the proximal parts of the bronchial tree, endobronchial laser Doppler flowmetry (LDF) was performed in 25 patients with CLL. The results were compared with the data of 20 people from the control group, who were conducted PBS and LDF. According to the research data in patients with CLL, in the process of tumor progression, various types and degree of severity of microcirculatory circulation were registered.
The LDF method is based on probing tissue by laser radiation and subsequent processing of radiation reflected from a tissue in accordance with the Doppler effect. The amount of probed tissue in the LDF method is determined by the geometry and optical parameters of the light probe. The amplitude of the reflected signal is formed as a result of the reflection of radiation from erythrocytes, moving at different speeds and differently quantitatively distributed in arterioles, capillaries, venules and arterial venous anastomosis. Thus, PM determines the change in blood flow per unit time in the volume of tissue being probed and is represented by the following expression: PM = K × Ner × Vav; where: PM – microhemocirculation parameter , K – proportionality coefficient, (K = 1), Ner – red blood cell count, Vav – average erythrocyte rate – tov in the probed volume . A decrease in the PM values may be due to a change in the number of blood cells and their speed in the microvessels of the area being examined. In CLL, microhemocirculation in the lungs and bronchi is undoubtedly promoted by accumulations of lymphocytes in small caliber vessels and anemic syndrome. In order to minimize the effect of anemia on the PM, in patients with group III (stage C, according to the J. Binet classification), the anemic syndrome was stopped before the study. The hemoglobin level during LDF was not lower than 100 × 10 9 / l, the content of red blood cells was at least 3 × 10 9 / l. Thus, they tried to establish a decrease in the speed of red blood cells in the microvessels, which in CLL may be primarily due to the presence of vascular accumulations of lymphocytes.