The functional state of the bronchopulmonary system in patients with chronic lymphocytic leukemia

An important reason contributing to the severe and protracted course of bronchopulmonary infections in CLL is pronounced secondary immunodeficiency. Therefore, the study of the functional state of the bronchopulmonary system of these patients began with a study of immunological parameters. All patients diagnosed with CLL significant inhibition of cellular and immune gumoralno- of ETA .

When conducting a spirographic study, violations of ventilatory function of the lungs (VFL) in obstructive and mixed types were detected only in patients who had long abused smoking, who had a diagnosis of COPD long before the first signs of CLL (50 people) appeared. In the remaining patients, even with a significant increase in the broncho-pulmonary lymph nodes, there were no violations of VFL during spirography.

To evaluate the bronchial permeability and its daily monitoring, peak flow metering was used, which was used to measure peak expiratory flow rate (PSV) for 1 to 2 weeks. This chapter provides data only for those patients who did not have a history of COPD and did not abuse smoking. In CLL patients of all groups, the PSV indices averaged 95% of the required values ​​in the morning and 100% in the evening. Daily fluctuations of PSV did not exceed the repeatability of the test and amounted to 5% of the initial value.

Indicators of bronchial resistance in patients with I (2.7 ± 0.1 / l / s on inspiration, 3.0 ± 0.14 / l / s on exhalation) and II (2, 8 ± 0.1 cm.water / l / s on inhalation, 3.0 ± 0.11 cm.water / l / s on exhalation) groups did not have significant differences compared with similar indicators in the control (2.8 ± 0.1 and 3.0 ± 0.06 see water supply / l / s, respectively). In patients with group III, there was an increase in bronchial resistance compared with the control (3.4 ± 0.11 cm. Water / l / s on inspiration; 3.5 ± 0.11 cm. Water / l / s / s on the exhale; P <0.001).

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